The Effects of Air Pollution on Respiratory Problems: A Literature Review


  • Hari Krismanuel Department of Surgery, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia
  • Nany Hairunisa Department of Occupational Medicine, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia


Air pollution, allergies, COPD, lung cancer, respiratory infections


As the global prevalence of air pollution continues to rise, understanding its intricate impact on human health, particularly respiratory well-being, becomes imperative. The research objectives of the article is to explore and establish clear connections between air pollution and respiratory health. Methods: A comprehensive search of peer-reviewed literature was conducted using databases such as PubMed, Web of Science, and Google Scholar. Articles published between 2015 and 2023 were included, with a focus on epidemiological studies, experimental research, and reviews that explored the impact of air pollution on respiratory problems. The result is this review synthesizes the established connections between these pollutants and a range of respiratory problems. Extensive evidence showcases how exposure to elevated pollutant levels escalates the risk of respiratory maladies, encompassing aggravated asthma, exacerbated chronic obstructive pulmonary disease (COPD) symptoms, compromised lung function, heightened susceptibility to respiratory infections, elevated lung cancer risk, and potentiated allergic responses. This review also underscores the heightened vulnerability of certain demographics, such as prenatal age, children, the elderly, individuals with preexisting respiratory conditions, low socioeconomic groups, occupational groups, outdoor workers, and athletes, immune-compromised individuals, and genetic susceptibility to these detrimental effects. The underlying mechanisms orchestrating the impact of air pollution on respiratory health involve intricate interplays of oxidative stress, inflammation, and tissue damage within the respiratory system. In conclusion: The study advocates for urgent and targeted strategies to mitigate the adverse impact of air pollution on respiratory health.


Manisalidis I, Stavropoulou E, Stavropou pos A, Bezirtzoglou E. Environmental and Health Impacts of Air Pollution: A review. Front Public Health 2020; 8:14. Available from: https://www.ncbi.nlm. nih. gov/pmc/articles /PmentMC7044178/

World Health Organization. Air pollution. 2022. air-pollution#tab=tab_1

Lee YG et al. Effects of Air Pollutants on Airway Diseases. Int J Environ Res Public Health. Sep 2021; 18(18): 9905. doi: 10.3390/ijerph18189905 Available from: articles/PMC8465980/

Kim D, Chen Z, Zhou LF, Huang SX. Air pollutants and early origins of respiratory disesases. Chronic Dis Transl Med. Jun 2018; 4(2): 75-94. %2Fj.cdtm.2018.03.003 Available from: articles/PMC6033955/

Cao Y et al. Environmental pollutants damage airway epithelial cell cilia: Implications for the prevention of obstructive lung diseases. Thorac Cancer. Mar 2020; 11(3): 505-510. 23 Available from: https://www.ncbi.nlm.

Wang S, Hua G, Zhou H. What are the Key Factors Affecting Air Pollution?. Sustainability. March 2020; 12(6): 2371. Avail-able from:

United States Environmental Protection Agency. Climate Impacts on Human Health. 2016.

United States Environmental Protection Agency. Climate Change Impacts on Air Quality. 2023. climateimpacts/climate-change-impacts-air-quality

Lai LW, Lin CY. Influence of the Geographic Channel Effect on PM2.5 Concentration over the Taipei Basin in Relation to Continental High-Pressure System during Winter. Atmosphere. 2022;13(10): 1539. 3390/atmos13101539 Available from: /1539

Queenland Government. Influence of meteorology on air quality: Meteorological Factors. 2017. environment/management/monitoring/air/air-monitoring/meteorology-influence

Mannan M, Al-Ghamdi SG. Indoor Air Quality in Buildings: A Comprehensive Review onthe Factors Influencing Air Pollution in Residential and Commercial Structure. Int. J. Environ. Res. Public Health 2021; 18(6): 3276; 10.3390/ijerph18063276. Available from: 3276

Son YS. A review on indoor and outdoor factors affecting the level of particulate matter in classrooms of elementary schools. Journal of Building Engineering. September 2023; Volume 75: 106957. from: https://www.sciencedirect. com/science/article/abs/pii/S2352710223011361

Holden KA, Lee AR, Hawcutt DB, Sinha IP. The impact of poor housing and indoor air quality on respiratory health in children. Breathe (Sheff). June 2023; 19(2): 230058. doi: 10.1183/20734735.0058-2023. Avail-able from: pmc/articles/PMC10461733/

Yaghi A, Dolovich MB. Airway Epithelial Cell Cilia and Obstructive Lung Disease. Cells. 2016; 5(4): 40. 3390/cells5040040. Available from: https: //www.mdpi. com/2073-4409/5/4/40

Adivitya et al. Mucociliary Respiratory Epithelium Integrity in Molecular Defense and Susceptibility to Pulmo-nary Viral Infections. Biology. 2021; 10(2):95. biolo gy10020095. Available from: https://pubmed.ncbi.nlm. 760/

Thangavel P, Park D, Lee YC. Recent Insights into Particulate Matter (PM2.5)-Mediated Toxicity in Humans : An Overview. Int J Environ Res Public Health. Jun 2022; 19(12): 7511. 10.3390%2Fijerph19127511. Available from: articles/PMC9223652/

Carlsten C, Salvi S, Wong GWK, Chung KF. Personal strategies to minimise effects of air pollution on respiratory health: advice for providers, patients and the public. Eur Respir J. June 2020; 55(6): 1902056. 56-2019 Available from: https://www.ncbi.

Knudsen L, Ochs M. The micromecha-nics of lung alveoli: structure and func-tion of surfactant and tissue compo-nents. Histochem Cell Biol. December 2018; 150(6): 661-676. s00418-018-1747-9 Available from: https://

Ochs M et al. On the Top of Alveolar Epithelium: Surfactant and the Glyco-calyx. Int. J. Mol. Sci. April 27, 2020 ; 21(9): 3075. ijms21093075 Available from: https: //

Lee PH et al. The Impact of Environ-mental Pollutants on Barrier Dysfunc-tion in Respiratory Disease. Allergy Asthma Immunol Res. November 2021; 13(6): 850-862. /10.4168/aair.2021. 13.6.850 Available from: https://www.ncbi. pmc/articles/PMC8569032/

Garcia et al. Toxicological Effects of Fine Particulate Matter (PM2.5): Health Risks and Associated Systemic Injuries-Sys-tematic Review. Water, Air,& Soil Pollution. May 24, 2023; 234: 346. https: // Available from: https: //link. article/10.1007/s11270-023-06278-9

Tiotiu AI et al. Impact of Air Pollution on Asthma Outcomes. Int J Environ Res Public Health. September 2020; 17(17): 6212. Available from: https://www.ncbi.nlm.

Meth M, Melegrito RAT. What to know about asthma and air pollution. Medical News Today. March 31, 2023. https: //

Moreno OB et al. Impact of Air Pollution on Asthma: A Scoping Review. Open Respir Arch. January 3, 2023;5(2): 100229. 100229. Available from: https://www.

United States Environmental Protection Agency. The Links Between Air Pollution and Childhood Asthma. October 22, 2018. sciencematters/links-between-air-pollu-tion-and-childhood-asthma

Orellano P et al. Effect of outdoor air pollution on asthma exacerbations in children and adults: Systematic review and multilevel meta-analysis. Plos One. March 20, 2017. pone.0174050. Available from: https:// 1371/journal.pone.0174050

Evangelopoulos D. Health impact assess-ment of current and past air pollution on asthma in London. the Environmental Research Group and Small Area Health Statistics Unit, Imperial College London. February 28, 2022.

Lee JT. Review of epidemiological studies on air pollution and health effects in children. Clin Exp Pediatr. June 10, 2020; 64(1): 3-11. https:// Avail-able from: jour-nal/view.php?number= 20125553659

Duan RR, Hao K, Yang T. Air pollution and chronic obstructive pulmonary disease. Chronic Dis Transl Med. December 2020; 6(4): 260-269. 2Fj.cdtm.2020.05.004 Available from: https://www.ncbi.nlm.nih. gov/pmc/articles/PMC7729117/

Park JY et al. Impact of long-term exposure to ambient air pollution on the incidence of chronic obstructive pulmonary disease: A systematic review and meta-analysis. Envi-ronmental Research. March, 2021. 194: 110703. 2020.110703 Available from: https://www. 5120316 029

Tahery et al. Chronic Obstructive Pulmonary Disease (COPD) and Air Pollution: A Review. Jundishapur Journal of Chronic Disease Care. February 7, 2021; 10(1): e110273. jjcdc.110273 Available from: https://brief

Wang L, Xie J, Hu Y, Tian Y. Air pollution and risk of chronic obstructed pulmonary disease: The modifying effect of genetic susceptibility and lifestyle. eBiomed. May 2022; 79: 103994. DOI:10.1016/j.ebiom. 2022.103994 Available from: https://www.

Xu QJ, Xiao DM, Di F. Air pollution and chronic airway diseases: what should people know and do?. Journal of Thoracic Disease, January 30, 2016; 8(1). 2015.11.50 Available from: https://

Garcia E, Rice MB, Gold DR. Air pollution and lung function in children. J Allergy Clin Immunol. July 2021; 148 (1): 1-14. doi: 10.1016/j.jaci.2021.05.006. Available from: articles/PMC8274324/

Markevych I et al. Residential greenspace and lung function decline over 20 years in a

prospective cohort: The ECRHS study. Environment International. 2023; 178: 18036. 2023.108036 Available from:

Kurt OK, Zhang J, Pinkerton KE. Pulmonary Health Effects of Air Pollution. Curr Opin Pulm Med. March 2016; 22(2): 138–143. 0000000000000248 Available from: https: // 42/pdf/nihms-759816.pdf

Burhan E, Mukminin U. A systematic review of respiratory infection due to air pollution during natural disasters. Medical Journal of Indonesia. March 2020; 29(1). Available from: index.php/mji/article/view/4390/1725

Raju S, Siddharthan T, McCormack MC. Indoor Air Pollution and Respiratory Healh. Clin Chest Med. December 2020; 41(4): 825-843. %2Fj.ccm.2020.08.014 Available from: PMC7665158/

Wibowo A, Saputro TT. Air Pollution-Induced Acute Respiratory Infection. JK Unila. October 2022; 6(1): 11-15. https:// Availa-ble from: id/index.php/JK/article/view/3014/2923

Domingo JL, Rovira J. Effects of air pollutants on the transmission and severity of respiratory viral infections. Environmen-tal Research. August 2022; 187: 109650. 50 Available from:

Aithal SS, Sachdeva I, Kurmi OP. Air quality and respiratory health in children. Breathe. 2023; 19: 230040. 10.1183/20734735.0040-2023 Available from: content/19/2/230040

Hill W et al. Lung adenocarcinoma promotion by air pollutants. Nature. April 5, 2023; 616: 159-167. doi: 10.1038/ s41586-023-05874-3. Available from:

Swanton C et al. LBA1 - Mechanism of action and an actionable inflammatory axis for air pollution induced non-small cell lung cancer: Towards molecular cancer prevention. Annals of Oncology. 2022; 33(7): S808-S869. https://oncologypro. ress/mechanism-of-action-and-an-action able-inflammatory-axis-for-air-pollution-induced-non-small-cell-lung-cancer-to wards-molecular-cancer-prevention

Liu X et al. Lung Cancer Death Attributable to Long-Term Ambient Particulate Matter (PM2.5) Exposure in East Asian Countries During 1990–2019. Front. Med; October 15, 2021; Volume 8. 10.3389/fmed.2021.742076. Available from: 10.3389/fmed.2021.742076/full

Lim JU, Yoon HK. Narrative review: association between lung cancer develop-ment and ambient particulate matter in never-smokers. Journal of Thoracic Disease February 28, 2022; 14(2). 10.21037/jtd-21-655. Available from:

Khan S et al. Lung cancer in never smokers (LCINS): development of a UK national research strategy. BJC Reports 1, July 20, 2023. Article number: 1 (2023). http://dx. Available from: articles/s44276-023-00006-w

Yang SI. Particulate matter and childhood allergic diseases. Korean Journal of Pediatrics 2019;62(1):22-29. https://doi. org/10.3345/kjp.2018.07045. Available from: php?number=20125553496

Melen E et al. Air pollution and IgE sensitization in 4 European birth cohorts—the MeDALL project. Environmental and Occupational Disease. February 2021; 147(2): 713-722. j.jaci.2020.08.030. Available from: https:// (20)31241-0/fulltext

Selzie et al. Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants. Environ Sci Technol. March 22, 2017; 51(8): 4119-4141. %2Facs.est.6b04908. Available from:

Heinrich J. Air pollutants and primary allergy prevention. Allergo J Int. October 10, 2018; 28: 5-15. /s40629-018-0078-7. Available from: https: //

Bowatte G. The influence of childhood traffic-related air pollution exposure on asthma, allergy and sensitization: a systematic review and a meta-analysis of birth cohort studies. Allergy. March 2015; 70(3): 245-256. 12561. Available from: https://online

Kim YB et al. Ambient air pollution and movement behaviours: A scoping review. Health and Place. November 2021; Volume 72: 102676. place.2021.102676. Available from: https:// abs/ pii/S1353829221001726

Dondi et al. Outdoor Air Pollution and Childhood Respiratory Disease: The Role of Oxidative Stress. Int J Mol Sci. March 2023; 24(5): 4345. doi: 10.3390/ijms24054 345. Available from: https://www.ncbi.

Wang Y, Huang Y, Li C. The Effects of Air Pollutants on Mortality in the Elderly at Different Ages: A Case of the Prefecture with Most Serious Aging in China. Sustainability. November 2023; 15(22): 15821. 21. Available from: /2071-1050/15/22/15821

Clarke et al. Prenatal Exposure to Ambient PM2.5 and Early Childhood Growth Impairment Risk in East Africa. Toxics. November 2022; 10: 705. 10.3390 /toxics10110705. Available from:

Hooper LG, Kaufman JD. Ambient Air Pollution and Clinical Implications for Susceptible Populations. Ann Am Thorac Soc. April 2018; 15(2): S64-S68. 201707-574mg. Available from: https:// PMC5955035/

United States Environmental Protection Agency. Which Populations Experience Greater Risks of Adverse Health Effects Resulting from Wildfire Smoke Exposure?

February 2024.

Xiang K et al. Association between ambient air pollution and tuberculosis risk: A systematic review and meta-ana lysis. Chemosphere. August 2021; Vol 277: 130342. j.chemosphere.2021.130342. Available from: science/article/abs/pii/ S004565352100 8122

World Health Organization. Ambient (outdoor) air pollution. December 19, 2022. fact-sheets/detail/ambient-(outdoor)-air-quality-and-health

Laumbach R, Meng Q, Kipen H. What can individuals do to reduce personal health risks from air pollution?. Journal of Thoracic Disease. January 26, 2015; Volume 7(1). issn.2072-1439.2014.12.21. Available from: view/3709/html

Bradley N. Review of interventions to improve outdoor air quality and public health. Public Health England. London. March 2019. Available from: https://as file/938623/Review_of_interventions_to_ improve_air_quality_March-2019-20185 72.pdf



How to Cite

Krismanuel, H., & Hairunisa, N. (2024). The Effects of Air Pollution on Respiratory Problems: A Literature Review. Poltekita : Jurnal Ilmu Kesehatan, 18(1), 1–15.



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