Analisis Kadar Interleukin-18 (Il-18) Serum dan Laju Filtrasi Glomerulus (GFR) Pada Obesitas Sentral dan Non Obesitas Sentral
Abstract
Interleukin-18 adalah proinflmasi dihasilkan di glomerulus, meningkat pada keadaan sindrom metabolik diawali dengan obesitas, diekskresikan setelah cedera iskemik ginjal. IL-18 merupakan biomarker untuk mendiagnosis kerusakan ginjal akut. Laju filtrasi glomerulus (LFG) adalah salah satu biomarker untuk menilai fungsi ginjal. Tujuan menganalisis kadar IL-18 dan LFG pada obesitas dan non obesitas sentral. Penelitian cross sectional, Sampel terdiri atas 40 subjek obesitas sentral dan 33 subjek non obesitas sentral. Kadar IL-18 serum diperiksa dengan kit human IL-18 dengan metode ELISA dan kreatinin serum menggunakan alat Clinical Chemistry Analyzer ABX Pentra. Hasil penelitian tidak terdapat perbedaan bermakna terhadap kadar Interleukin-18 antara kelompok obesitas sentral dan non obesitas sentral (p=0,576) sedangkan nilai LFG pada subjek obesitas sentral memiliki nilai rerata yang lebih tinggi yaitu 103,17 ml/min/1,73m2 dibandingkan dengan subjek non obesitas sentral yaitu 96,47 ml/min/1,73m2 dan secara statistik tidak menunjukkan adanya perbedaan bermakna pada nilai LFG subyek laki-laki dengan obesitas sentral dan non obesitas sentral (p=0,207). Pada analisis ini tidak ditemukan korelasi antara kadar IL-18 dan GFR pada kelompok obesitas dan non obesitas sentral (r=-0.047 p=0,695).
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