Combination of Eucheuma Cottonii and Corticosteroids has a Superior Immunomodulatory Effect on Asthma
Abstract
Asthma prevalence has been increasing globally which is commonly treated using corticosteroid as gold standard treatment. However, corticosteroids have adverse effects and cases of corticosteroid-resistant asthma are emerging. Eucheuma cottonii (EC) has been shown to potentially attenuate inflammatory response in type I hypersensitivity. This study aimed to investigate the effect of Eucheuma cottonii extract and methylprednisolone combination on IL-4, IL-10, and histamine levels in Ovalbumin-induced asthma BALB/c mice. Thirty female BALB/c mice were randomly assigned to 6 groups : (1) Sham; (2) Ovalbumin-induced asthma mice; (3) Ovalbumin-induced asthma mice treated with methylprednisolone (MP) 0.24 mg/day; (4) Ovalbumin-induced asthma mice treated with EC extract 300 mg/kgBW/day; (5) Ovalbumin-induced asthma mice treated with combination of both. Treatments were given respectively for 7 days. Plasma IL-4, IL-10, and histamine levels were measured using ELISA method. The combination group showed both the lowest IL-4 levels (89.30 ± 1.37 pg/ml) and the highest IL-10 levels (487.03 ± 20.57 pg/ml) compared to other asthma-like mouse groups (p = 0.001). No significant difference was observed in histamine levels among all treatments (p > 0.05). The administration of a combination of methylprednisolone and Eucheuma cottonii extract significantly affected plasma IL-4 and IL-10 levels compared to monotherapies. However, there was no significant difference in plasma histamine levels compared to monotherapies.
How to Cite
Views / Downloads
Files
License
Authors who publish with Poltekita : Jurnal Ilmu Kesehatan agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
This work is licensed under a Creative Commons Attribution-ShareAlike 2.0 Generic License.
Poltekita : Jurnal Ilmu Kesehatan is licensed under a Creative Commons Attribution-Share Alike 4.0 International License
You are free to:
- Share, copy and redistribute the material in any medium or format
- Adapt, remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
References
Dharmage SC, Perret JL, Custovic A. Epidemiology of Asthma in Children and Adults. Frontiers in pediatrics. 2019;7:246.
Stern J, Pier J, Litonjua AA. Asthma epidemiology and risk factors. Seminars in immunopathology. 2020 Feb;42(1):5–15.
Yasir M, Goyal A, Sonthalia S. Corticosteroid Adverse Effects. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023.
Henderson I, Caiazzo E, McSharry C, Guzik TJ, Maffia P. Why do some asthma patients respond poorly to glucocorticoid therapy? Pharmacol Res. 2020 Oct;160:105189.
Sudirman S, Hsu YH, He JL, Kong ZL. Dietary polysaccharide-rich extract from Eucheuma cottonii modulates the inflammatory response and suppresses colonic injury on dextran sulfate sodium-induced colitis in mice. PloS one. 2018;13(10):e0205252.
Ivashkin V, Zolnikova O, Potskherashvili N, Trukhmanov A, Kokina N, Dzhakhaya N, et al. Metabolic Activity of Intestinal Microflora in Patients with Bronchial Asthma. Clinics and Practice. 2019;9(1):1126.
Igbe I, Shen XF, Jiao W, Qiang Z, Deng T, Li S, et al. Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase. Oncotarget. 2017 Dec 26;8(69):113734–48.
Molitorisova M, Sutovska M, Kazimierova I, Barborikova J, Joskova M, Novakova E, et al. The anti-asthmatic potential of flavonol kaempferol in an experimental model of allergic airway inflammation. Eur J Pharmacol. 2021 Jan 15;891:173698.
Abu Bakar N, Anyanji VU, Mustapha NM, Lim SL, Mohamed S. Seaweed (Eucheuma cottonii) reduced inflammation, mucin synthesis, eosinophil infiltration and MMP-9 expressions in asthma-induced rats compared to Loratadine. Journal of Functional Foods. 2015;19:710–22.
Tan D, Lu M, Cai Y, Qi W, Wu F, Bao H, et al. SUMOylation of Rho-associated protein kinase 2 induces goblet cell metaplasia in allergic airways. Nat Commun. 2023 Jul 1;14(1):3887.
Huang H, Li Y, Liang J, Finkelman FD. Molecular Regulation of Histamine Synthesis. Front Immunol. 2018;9:1392.
Xu SS, Liu QM, Xiao AF, Maleki SJ, Alcocer M, Gao YY, et al. Eucheuma cottonii Sulfated Oligosaccharides Decrease Food Allergic Responses in Animal Models by Up-regulating Regulatory T (Treg) Cells. Journal of Agricultural and Food Chemistry. 2017;65(15):3212–22.
Wang Q, Zhang L, He Y, Zeng L, He J, Yang Y, et al. Effect of κ-carrageenan on glucolipid metabolism and gut microbiota in high-fat diet-fed mice. Journal of Functional Foods. 2021 Nov;86:104707.
McLoughlin R, Berthon BS, Rogers GB, Baines KJ, Leong LEX, Gibson PG, et al. Soluble fibre supplementation with and without a probiotic in adults with asthma: A 7-day randomised, double blind, three way cross-over trial. EBioMedicine. 2019 Aug;46:473–85.
Lee H ju, Park HJ, Starkweather A, An K, Shim I. Decreased Interleukin-4 Release from the Neurons of the Locus Coeruleus in Response to Immobilization Stress. Mediators lamm. 2016;2016:3501905.
Similar Articles
Similar Articles
- Novie Elvinawaty Mauliku, Andy Yudistira, Hotma Rumahorbo, Iin Inayah, Susilawati Susilawati, The Effect of Acupressure on Increasing Oxygen Saturation in Pneumonia Patients , Poltekita: Jurnal Ilmu Kesehatan: Vol. 17 No. 4 (2024): February
- Yurmianna Marlina Hasibuan, Ishak Aziz, Arsil Arsil, Nuridin Widya Pranoto, Eri Barlian, Fiky Zarya, Tendy Roy, Validity and Reliability of Physical Fitness Test of Nusantara Students at SMP Padang City , Poltekita: Jurnal Ilmu Kesehatan: Vol. 17 No. 4 (2024): February
- Dahrizal, Idramsyah, Septiyanti, Clinical Retrospective Cohort Study on the Effectiveness of Chitosan Zinc Oxide Cream for Accelerating Healing in Diabetic Ulcer Patients , Poltekita: Jurnal Ilmu Kesehatan: Vol. 19 No. 1 (2025)
- Husni, Asmawati, Kelana Kusuma Dharma, The Impact of the Education Program for Stroke (EPSTRO) on Family Caregivers’ Competence in Home-Based Stroke Care , Poltekita: Jurnal Ilmu Kesehatan: Vol. 19 No. 3 (2025)
- Andi Suhenda, Diana Barsasella, Ari Sukawan, Dedi Setiadi, Sugiharto, Prima Soultoni Akbar, Analysis of the Causes of Medical Records Document Misfiling at Makassar City Regional General Hospital , Poltekita: Jurnal Ilmu Kesehatan: Vol. 19 No. 2 (2025)
- Nilda Yulita Siregar, Silfana Hiola, Nurfatimah Nurfatimah, Faktor yang Berhubungan dengan Kejadian Anemia dalam Kehamilan Trimester III di Wilayah Kerja Puskesmas Mapane: Factors Related to The Incidence of Anemia in The Third Trimester of Pregnancy in The Work Area of The Mapane Community Health Center , Poltekita: Jurnal Ilmu Kesehatan: Vol. 13 No. 2 (2019): October
- Dafrosia Darmi Manggasa, Agusrianto Agusrianto, Muhamad Fikran Djua, Kombinasi Contrast Bath dengan Foot Massage Menurunkan Edema Kaki Pada Pasien Congestive Heart Failure , Poltekita: Jurnal Ilmu Kesehatan: Vol. 15 No. 1 (2021): May
- Rahmi Permatasari, Andi Liliandriani, The Implementasi Kegiatan Imunisasi Posyandu dengan Menggunakan Juknis Imunisasi pada masa Pandemi Covid -19 , Poltekita: Jurnal Ilmu Kesehatan: Vol. 15 No. 3 (2021): November
- Nabila Rahma Salsa, Inge Dhamanti, Akses Pelayanan Kesehatan Ibu dan Anak di Puskesmas Selama Pandemi Covid-19 , Poltekita: Jurnal Ilmu Kesehatan: Vol. 15 No. 4 (2022): February
- Muhammad Rifqy Rifandy, Marselinus Laga Nur, Rut Rosina Riwu, Hubungan Perilaku Ibu dalam Pemberian Asi Eksklusif dan Pemberian MP-ASI terhadap Kejadian Stunting di Kelurahan Naioni Kota Kupang , Poltekita: Jurnal Ilmu Kesehatan: Vol. 16 No. 3 (2022): November
You may also start an advanced similarity search for this article.
