Sediaan “RAJALOM” (Ramuan Jamu Lombok) terhadap Kadar Asam Urat Plasma dan Gambaran Histopatologi Aorta Rattus novergicus
"RAJALOM" (Herb Herbal Lombok) Levels of Plasma Gout and Picture Histopathology Aortic Rattus novergicus
Abstract
Hiperurisemia penyebab radang sendi memerlukan penatalaksanaan pengobatan menggunakan bahan-bahan alam. Tujuan penelitian ini untuk mengkaji aktivitas ramuan khas Lombok RAJALOM terhadap kadar asam urat pada plasma dan urin serta mempengaruhi gambaran histopatologi aorta pada hewan coba Rattus novergicus dengan hiperuricema diinduksi diet tinggi kolesterol dan purin. Penelitian ini menggunakan hewan coba Rattus norvegicus yang diinduksi dengan diet tinggi purin dan koleterol dikombinasi potasium oksanat IP 42 mg/200 kkBB tikus. Tikus putih dibagi menjadi 8 kelompok. Tikus putih hiperurecemia diberikan perlakuan pemberian aquades per sonde untuk kelompok kontrol negatif, alopurinol 1,8 mg/200gram BB Tikus untuk kelompok kontrol positif dan kelompok perlakuan diberikan ramuan khas Lombok RAJALOM. Pada akhir perlakuan diambil sampel darah, urin dan aorta untuk pemeriksaan kadar asam urat plasma, kadar asam urat urin dan gambaran histopatologi aorta. Hasil penelitian pemberian ramuan jamu dari Lombok RAJALOM selama 7 dan 14 hari mampu menurunkan kadar asam urat plasma hewan coba dengan rentang antara dan 45,7 %- 77,27 %, sedangkan pada kelompok kontrol positif / Allopurinol mampu menurunkan sampai dengan 86 % pada hari ke 14. Tidak terdapat hubungan yang signifikan antara kelompok perlakuan terhadap kadar asam urat plasma hewan coba pada hari ke 7 dan hari ke 14.Tidak terdapat perbedaan yang signifikan antara kadar asam urat sebelum perlakuan dengan sesuadah perlakuan pada semua kelompok penelitian. Pemberian induksi dengan pakan tinggi lemak/purin selama 3 minggu pada hewan coba tikus (Rattus Novergicus) tidak menimbulkan terbentuknya plak aterosklerosis. Kesimpulan pemberian ramuan jamu dari Lombok RAJALOM selama 7 dan 14 hari mampu menurunkan kadar asam urat plasma hewan.
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