Evaluasi Klinis dan Efek Samping Terapi Obat Antivirus Pada Pasien Covid-19 Di RSPAD Gatot Soebroto
Abstract
Tujuan penelitian ini adalah untuk menganalisa hubungan jenis obat antivirus Covid-19 dengan outcome klinis dan lama rawat berdasarkan derajat keparahan Covid-19 di ruang rawat inap Paviliun Soehardo Kertohusodo RSPAD Gatot Soebroto Jakarta. Penelitian ini merupakan penelitian observasional analitik dan pengambilan data secara retrospektif melalui rekam medis periode bulan September - November tahun 2020. Sampel adalah pasien Covid-19 derajat sedang dan berat. Data demografi dan klinis pasien serta profil pengobatan dianalisis secara deskriptif berdasarkan derajat keparahan Covid-19. Analisis data yaitu uji Spearman’s rho. Hasil menunjukkan terdapat 79 pasien Covid-19 yang memenuhi kriteria inklusi dengan derajat sedang 62,03% dan derajat berat 37,97%. Penggunaan antivirus pada derajat sedang yaitu oseltamivir sebanyak 28 pasien (57,14%), favipiravir 13 pasien (26,53%) sedangkan penggunaan antivirus pada derajat berat adalah oseltamivir & favipiravir. Hubungan lama status positif RT-PCR dan lama rawat terhadap derajat keparahan Covid-19 diperoleh p <0,05. Hubungan profil penggunaan obat antivirus dengan derajat keparahan Covid-19 diperoleh p=0,00. Hubungan jenis regimen obat antivirus dengan nilai skala rasio parameter klinik d-dimer pre p=0,01 dan post p=0,03 dan parameter klinik SGPT (pre) p=0,04 da (post) p=0,00 pada derajat berat. Kesimpulan yaitu terdapat hubungan yang signifikan profil penggunaan regimen obat antivirus dengan derajat keparahan Covid-19 dan terdapat hubungan yang signifikan pada penggunaan obat penunjang yaitu antikoagulan, antihistamin, obat gangguan saluran cerna dan obat hepaprotektor dengan derajat keparahan Covid-19
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