Analisis Kadar Interleukin-18 (Il-18) Serum dan Laju Filtrasi Glomerulus (GFR) Pada Obesitas Sentral dan Non Obesitas Sentral
Abstract
Interleukin-18 adalah proinflmasi dihasilkan di glomerulus, meningkat pada keadaan sindrom metabolik diawali dengan obesitas, diekskresikan setelah cedera iskemik ginjal. IL-18 merupakan biomarker untuk mendiagnosis kerusakan ginjal akut. Laju filtrasi glomerulus (LFG) adalah salah satu biomarker untuk menilai fungsi ginjal. Tujuan menganalisis kadar IL-18 dan LFG pada obesitas dan non obesitas sentral. Penelitian cross sectional, Sampel terdiri atas 40 subjek obesitas sentral dan 33 subjek non obesitas sentral. Kadar IL-18 serum diperiksa dengan kit human IL-18 dengan metode ELISA dan kreatinin serum menggunakan alat Clinical Chemistry Analyzer ABX Pentra. Hasil penelitian tidak terdapat perbedaan bermakna terhadap kadar Interleukin-18 antara kelompok obesitas sentral dan non obesitas sentral (p=0,576) sedangkan nilai LFG pada subjek obesitas sentral memiliki nilai rerata yang lebih tinggi yaitu 103,17 ml/min/1,73m2 dibandingkan dengan subjek non obesitas sentral yaitu 96,47 ml/min/1,73m2 dan secara statistik tidak menunjukkan adanya perbedaan bermakna pada nilai LFG subyek laki-laki dengan obesitas sentral dan non obesitas sentral (p=0,207). Pada analisis ini tidak ditemukan korelasi antara kadar IL-18 dan GFR pada kelompok obesitas dan non obesitas sentral (r=-0.047 p=0,695).
How to Cite
Views / Downloads
Files
License
Authors who publish with Poltekita : Jurnal Ilmu Kesehatan agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
This work is licensed under a Creative Commons Attribution-ShareAlike 2.0 Generic License.
Poltekita : Jurnal Ilmu Kesehatan is licensed under a Creative Commons Attribution-Share Alike 4.0 International License
You are free to:
- Share, copy and redistribute the material in any medium or format
- Adapt, remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
References
Ikrar T, States U. Interleukin 18, Biomarkers of Acute Kidney Injury. 2017;(March).
Monteiro R, Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm. 2010;2010(Atp Iii).
Verdiansah. Pemeriksaan Fungsi Ginjal. CDK. 2016;43(2):148–54.
Graf L, Reidy K, Kaskel FJ. Nutrition management in childhood kidney disease: An integrative and lifecourse approach. Pediatr Nephrol Seventh Ed. 2015;341–60.
Savino A, Pelliccia P, Chiarelli F, Mohn A. Obesity-related renal injury in childhood. Horm Res Paediatr. 2010;73(5):303–11.
Wahba IM, Mak RH. Obesity and obesity-initiated metabolic syndrome: Mechanistic links to chronic kidney disease. Clin J Am Soc Nephrol. 2007;2(3):550–62.
Wang Y, Beydoun MA. The obesity epidemic in the United States - Gender, age, socioeconomic, racial/ethnic, and geographic characteristics: A systematic review and meta-regression analysis. Epidemiol Rev. 2007;29(1):6–28.
Hsu CY, McCulloch CE, Iribarren C, Darbinian J, Go AS. Body mass index and risk for end-stage renal disease. Ann Intern Med. 2006;144(1):21–8.
Kurniawan LB, Bahrun U, Hatta M, Arif M. BMI and Waist Circumference Have Positive Correlation With Mitochondrial DNA Copy Number in Young Adult Male. Open Obes J. 2018;8(1):1–6.
Nakamura A, Shikata K, Nakatou T, Kitamura T, Kajitani N, Ogawa D, et al. Combination therapy with an angiotensin-converting-enzyme inhibitor and an angiotensin II receptor antagonist ameliorates microinflammation and oxidative stress in patients with diabetic nephropathy. J Diabetes Investig. 2013;4(2):195–201.
Di Cesar DJ, Ploutz-Snyder R, Weinstock RS, Moses AM. Vitamin D deficiency is more common in type 2 than in type 1 diabetes [6]. Diabetes Care. 2006;29(1):174.
Rodriques RA, Sulchan M. Kadar Pro-Inflmator Sitokin Interleukin (IL)- 18 Pada Remaja Obesitas dengan Sindrom Metabolik. J Nutr Coll. 2014;3(3):404–13.
Widiana IGR. Bali Uro-Nephrology Scientific Communication. Bali. 2017.
Lestari YA. Korelasi Obesitas Dengan Laju Filtrasi Glomerulus (Lfg) Di Rs Muhammadiyah Palembang. 2019.
Kawamoto R, Kohara K, Tabara Y, Miki T, Ohtsuka N, Kusunoki T, et al. An association between body mass index and estimated glomerular filtration rate. Hypertens Res. 2008;31(8):1559–64.
Malik RHA. Perbedaan Kadar Interleukin 18 pada pasien nefropati diabetik dan non nefropati diabetik. 2019.
Insani DA, Subagio HW, Hendrianingtyas M. Iron status and hepcidin levels as potential regulators of haemoglobin homeostasis in overweight and obese women of childbearing age. J Taibah Univ Med Sci [Internet]. 2019;14(6):531–7. Available from: https://doi.org/10.1016/j.jtumed.2019.08.007
Similar Articles
Similar Articles
- Naufal Jihad Alfalah, Dita Hasni, Budi Yulhasfi Febrianto, Nilas warlem, Hubungan Obesitas dengan Kejadian Hipertensi pada Perempuan Minangkabau , Poltekita: Jurnal Ilmu Kesehatan: Vol. 15 No. 4 (2022): February
- Hardyansa, Liong Boy Kurniawan, Yuyun Widaningsih, Kolerasi Indeks Obesitasa dengan Kadar Neutrophil Gelatinase Associated Lipocalin (NGAL) pada Subyek Dewasa Non-Diabetes Melitus , Poltekita: Jurnal Ilmu Kesehatan: Vol. 15 No. 4 (2022): February
- Ririn Afrianto, Tien Tien, Nina Indriyani, Tety Yuniarty Sudiro, Andi Noor Kholidha Syarifin, Haryati Haryati, Pengaruh Extra Virgin Olive Oil (EVOO) Terhadap Kadar Lipid dan Indeks Massa Tubuh Wanita Obesitas Usia Produktif , Poltekita: Jurnal Ilmu Kesehatan: Vol. 16 No. 2 (2022): August
- Indriono Hadi, Lilin Rosyanti, Akhmad, Alfi Syahar Yakub, The Impact of Complementary Cupping Therapy on Immunity Changes (Interleukin-10) in Coastal Fishermen with Hypertension , Poltekita: Jurnal Ilmu Kesehatan: Vol. 19 No. 1 (2025)
- Suharno, Slamet Wardoyo, Taufik Anwar, Perbedaan Penggunaan Komposter An-Aerob dan Aerob Terhadap Laju Proses Pengomposan Sampah Organik , Poltekita: Jurnal Ilmu Kesehatan: Vol. 15 No. 3 (2021): November
- Sevia Dwi Suryanti, Anggi Tunjung Raras, Cleonara Yanuar Dini, Adhe Hariani Ciptaningsih, Hubungan Indeks Massa Tubuh dengan Kadar Gula Darah Puasa pada Pasien Diabetes Melitus Tipe 2: The Relationship of The Body Mass Index With Fast Blood Sugar Levels In Patients of Diabetes Mellitus Type 2 , Poltekita: Jurnal Ilmu Kesehatan: Vol. 13 No. 2 (2019): October
- St. Malka, Mutmainnah, Musni, Muliani, Faktor - faktor yang Berhubungan dengan Hipertensi Gestasional , Poltekita: Jurnal Ilmu Kesehatan: Vol. 15 No. 4 (2022): February
- Made Agus Hendrayana, I Gusti Kamasan Nyoman Arijana, The Effect of Anthocyanins from Purple Sweet Potato Extract In-vitro on IL-6 mRNA Expression in PBMC Cell Cultures Infected With Hepatitis B Virus , Poltekita: Jurnal Ilmu Kesehatan: Vol. 20 No. 2 (2026)
- Marta Sovianti Hulu, Dina Lusiana Setyowati, Reny Noviasty, Analisis Status Gizi dengan Pola Asuh Ibu, Ketahanan Pangan dan Asupan Gizi Di Pusat Pengembangan Anak (PPA) Samarinda , Poltekita: Jurnal Ilmu Kesehatan: Vol. 16 No. 2 (2022): August
- Lailiyatul Munawaroh, Yati Sri Hayati, Laily Yuliatun, The Effect of Interpersonal Communication Skills, Social Support, and Coping Strategy on Resilience in Master of Nursing Students Who Work on Thesis , Poltekita: Jurnal Ilmu Kesehatan: Vol. 17 No. 4 (2024): February
You may also start an advanced similarity search for this article.
